1 Now in the church that was at Antioch there were certain prophets and teachers: Barnabas, Simeon who was called Niger, Lucius of Cyrene, Manaen who had been brought up with Herod the tetrarch, and Saul. 2 As they ministered to [served; worshipped] the Lord and fasted, the Holy Spirit said, “Now separate to Me Barnabas and Saul for the work to which I have called them.” 3 Then, having fasted and prayed, and laid hands on them, they sent them away.

“ministered to” – Leitourgeo – to assume an office which must be administered at one’s own expense. This is an interesting word – the origin of our word liturgy. So, as our usage has developed, liturgy is the work or service that we owe to God. The work of worship is what God expects of us.

As to the broader sense of the text – 1. The church has prophets and teachers, and they are dedicated to the work of worship, and experiencing power through fasting. 2. The group is multicultural and multiracial. 3. The Holy Spirit speaks to the leaders of the church. 4. Having heard God’s direction, they returned to fasting and prayer. 5. The commissioning of ministers includes the laying on of hands.
Again, the centrality of worship and fasting by the leaders of the church opening up room for God to move and further His purposes.